It follows their narrow 20 -24 defeat by the Leicester Tigers last Saturday.
Phil Dollman and Jack Nowell both return for the first time this season, taking over from Ceri Sweeney and Jack Arnott.
Two changes have been made to the starting line-up with Ben Moon coming in for Carl Rimmer, while Damian Welch comes in instead of Ryan Caldwell.
Majority of Devon MPs back assisted dying bill
Just three of Devon's 13 MPs voted against the bill
Crime panel member calls for commissioner to resign
It's in the wake of the suspension of acting Chief Constable Jim Colwell
City footballers take time out to spread some festive cheer
Exeter stars bring joy to children in hospital
Calls for more control over spending
Many projects coming in over budget
Election cycle change thrown out in Plymouth
Annual elections will still be held in the city
